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Background and Aims
Parkinson¡¯s disease (PD) is the second most common chronic neurodegenerative disorder. PD is clinically characterized by a constellation of motor and nonmotor symptoms that may have a direct effect on daily activities as well as in the quality of life of the patient. Identifying the symptoms more closely associated with a poor quality of life is central on improving the medical care of the patient. We undertook this study to identify and describe the clinical and demographic factors that predict health-related quality of life among Mexican patients with PD.
Methods
One hundred seventy-seven patients with Parkinson¡¯s disease were included. Patients were evaluated using the following clinimetric instruments: motor subscale of the Unified Parkinson¡¯s disease rating scale, Hoehn and Yahr stage, Non-motor Symptoms Questionnaire, Parkinson¡¯s disease Questionnaire (PDQ-39) and the Mini Mental Status Examination.
Results
Multivariate analysis showed that the main factors associated with a poor quality of life were motor impairment (¦Â?= 0.27, p <0.001) and the number of nonmotor symptoms (¦Â?= 2.17, p <0.001). The main nonmotor domains impacting on the quality of life were depression/anxiety (¦Â?= 6.36, p <0.001), cardiovascular (¦Â?= 5.39, p?= 0.001), memory (¦Â?= 4.64, p <0.001) and miscellaneous (¦Â?= 3.15, p?= 0.001).
Conclusions
Both motor and mainly nonmotor symptoms are negatively associated with health-related quality of life in patients with PD and should be appropriately attended in order to improve patient care.
