Stressful learning paradigm precludes manifestation of cognitive ability in sphingomyelin synthase-2 knockout mice

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• 作者：Min Wang^a ; ^c ; ^d ; Osamu Uchiumi^a ; Hideo Ogiso^b ; Yuan Shui^a ; Jingyu Zou^a ; ^e ; Chieko Hashizume^b ; Makoto Taniguchi^b ; ^c ; Toshiro Okazaki^b ; Nobuo Kato^a ; ^{kato@kanazawa-med.ac.jp}
• 关键词：Novel object recognition test ; Context-dependent fear learning ; Morris water maze ; Long-term potentiation ; Paired-pulse facilitation ; Synaptic plasticity
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：319
• 期：Complete
• 页码：25-30
• 全文大小：732 K
• 卷排序：319

文摘

Sphingomyelin synthase 2 knockout (SMS2KO) mice well perform object recognition. Contextual fear memory was normal, but Morris water maze learning was not. Basic synaptic transmission in hippocampal CA1 was normal in SMS2KO mice. SMS2KO modified short- and long-term synaptic plasticity at CA1 synapses.