8-Methoxyquinolines as PDE4 inhibitors

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• 作者：Billah ; Motasim ; Buckley ; George M. ; Cooper ; Nicola ; Dyke ; Hazel J. ; Egan ; Robert ; Ganguly ; Ashit ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2002
• 出版时间：June 17, 2002
• 年：2002
• 卷：12
• 期：12
• 页码：1617-1619
• 全文大小：153 K

文摘

The synthesis and pharmacological profile of a novel series of 2-substituted 8-methoxyquinolines is described. The 2-trifluoromethyl compound was found to be a potent inhibitor of phosphodiesterase type 4 (PDE4).