A Bacteriophage Capsid Protein Provides a General Amyloid Interaction Motif (GAIM) That Binds and Remodels Misfolded Protein Assemblies

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A Bacteriophage Capsid Protein Provides a General Amyloid Interaction Motif (GAIM) That Binds and Remodels Misfolded Protein Assemblies

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作者：Rajaraman Krishnan¹ ; ^&dagger ; ; ^{rkrishnan@neurophage.com" class="auth_mail} ; Haim Tsubery¹ ; ^&dagger ; ; Ming Y. Proschitsky¹ ; Eva Asp¹ ; Michal Lulu¹ ; Sharon Gilead¹ ; Myra Gartner¹ ; Jonathan P. Waltho² ; ³ ; Peter J. Davis³ ; Andrea M. Hounslow³ ; Daniel A. Kirschner⁴ ; Hideyo Inouye⁴ ; David G. Myszka⁵ ; Jason Wright¹ ; Beka Solomon⁶ ; Richard A. Fisher¹ ; ^{rfisher@neurophage.com" class="auth_mail}
关键词：AD ; Alzheimer's disease ; BSA ; bovine serum albumin ; EDTA ; ethylenediaminetetraacetic acid ; HFIP ; hexafluoroisopropanol ; 1D ; one-dimensional ; MAb ; monoclonal antibody ; g3p ; gene 3 protein ; GAIM ; general amyloid interaction motif ; LCP ; luminescent conjugated polythiophene ; PTMI ; polythiophenes methyl imidazole ; PBS ; phosphate-buffered saline ; ThT ; thioflavin T ; CA ; cellulose acetate ; TROSY ; transverse relaxation optimized spectroscopy ; H/D ; hydrogen/deuterium ; RIPA ; radioimmunoprecipitation assay
刊名：Journal of Molecular Biology
出版年：26 June 2014
年：2014
卷：426
期：13
页码：2500-2519
全文大小：1562 K

文摘

•: Phage capsid protein g3p recognizes amyloid fold.
•: g3p(N1N2) binding to amyloids reflects structure function of g3p during infection.
•: Recombinant bivalent g3p molecules remodel amyloids generically.
•: g3p acts a general amyloid interaction motif.

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