Metabolic responses of the isopod Porcellionides pruinosus to nickel exposure assessed by <sup>1</sup>H NMR metabolomics

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Metabolic responses of the isopod Porcellionides pruinosus to nickel exposure assessed by ¹H NMR metabolomics

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作者：Nuno G.C. Ferreira^a ; Raquel Saborano^b ; Rui Morgado^a ; Diogo N. Cardoso^a ; Clá ; udia M. Rocha^b ; Amadeu M.V.M. Soares^a ; Susana Loureiro^a ; ^{sloureiro@ua.pt" class="auth_mail" title="E-mail the corresponding author} ; Iola F. Duarte^b ; ^{ioladuarte@ua.pt" class="auth_mail" title="E-mail the corresponding author}
关键词：Terrestrial isopods ; NMR spectroscopy ; Metabolomics ; Nickel ; Environmental risk assessment
刊名：Journal of Proteomics
出版年：2016
出版时间：30 March 2016
年：2016
卷：137
期：Complete
页码：59-67
全文大小：1415 K

文摘

•: Over 50 metabolites were identified in the isopod species P. pruinosus by NMR.
•: The metabolome changed with time, reflecting growth and adaptation to the environment.
•: Nickel induced time- and dose-dependent changes in the isopods metabolome.
•: Changes related to moulting, osmoregulation and detoxification were highlighted.
•: NMR metabolomics can aid mechanistic understanding of Ni handling by model organisms.

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