A phase 2b randomized, controlled trial of the efficacy of the GMZ2 malaria vaccine in African children
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文摘
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The GMZ2 fusion protein consist of the non-repeat region of falciparum GLURP genetically fused to a msp3 fragment.

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The GMZ2 fusion protein elicited functional antibodies in phase 1 studies.

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In the ATP analysis, vaccine efficacy adjusted for age and site was 14% (95% CI: 3.6%, 23%).

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Vaccine efficacy was higher in older children.

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In GMZ2-vaccinated children, the incidence of malaria decreased with increasing vaccine-induced anti-GMZ2 IgG concentration.

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