Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-κB and mTOR signaling

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Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-κB and mTOR signaling

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作者：Tharinee Mattaveewong^a ; Preedajit Wongkrasant^a ; Sumalee Chanchai^b ; Rath Pichyangkura^c ; Varanuj Chatsudthipong^a ; ^d ; ^e ; Chatchai Muanprasat^a ; ^d ; ^e ; ^{chatchai.mua@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author}
关键词：Colorectal cancer ; Chemoprevention ; Chitosan oligosaccharide ; AMP-activated protein kinase
刊名：Carbohydrate Polymers
出版年：2016
出版时间：10 July 2016
年：2016
卷：145
期：Complete
页码：30-36
全文大小：1529 K

文摘

•: Chitosan oligosaccharides (COS) inhibited colorectal cancer growth in mice.
•: COS stimulated AMPK and suppressed NF-κB and mTOR signaling in colon tissues.
•: COS inhibited MMP-9 expression.
•: Oral administration of COS showed no systemic toxicity in mice.

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