Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion

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• 作者：Julia E. Sero¹ ; ² ; ^{juliasero@post.harvard.edu} ; Chris Bakal¹
• 关键词：YAP ; beta-PIX ; Rac1 ; Cdc42 ; FAK ; adhesion ; cell shape ; mechanobiology ; morphology ; breast cancer
• 刊名：Cell Systems
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：4
• 期：1
• 页码：84-96.e6
• 全文大小：5364 K
• 卷排序：4

文摘

Multiparametric analysis of cell morphology identifies direct regulators of YAP Rac1/Cdc42 signaling through β-PIX couples YAP to cell-matrix adhesion YAP is regulated through FAK-dependent and -independent mechanisms during spreading YAP is uncoupled from adhesion dynamics in triple-negative breast cancer cells