Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5

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Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5

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作者：Guanghui Qian^a ; ^b ; ¹ ; Ying Ren^a ; ¹ ; Yibo Zuo^a ; Yukang Yuan^a ; Peng Zhao^a ; Xiaofang Wang^a ; Qiao Cheng^a ; Jin Liu^a ; Liting Zhang^a ; Tingting Guo^a ; Chang Liu^a ; ^{eygjgk@163.com" class="auth_mail" title="E-mail the corresponding author} ; Hui Zheng^a ; ^{huizheng@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Protein ubiquitination ; Proteasomal degradation ; E3 ligase ; Smurf1 ; USP5
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：3 June 2016
年：2016
卷：474
期：3
页码：491-496
全文大小：783 K

文摘

•: 10">Smurf1 down regulates the protein expression of USP5 in a ligase-activity dependent manner.
•: 15">Smurf1 constitutively interacts with USP5.
•: Smurf1 down regulates the stability and up regulates the ubiquitination level of USP5.
•: Smurf1 inhibits TNFα production through down-regulation of USP5.

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