The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass

详细信息查看全文

作者：Oren Rom ; ^{orenrom@tx.technion.ac.il" class="auth_mail" title="E-mail the corresponding author} ; Abraham Z. Reznick
关键词：4E BP ; eukaryotic translation initiation factor-4E-binding protein ; Akt ; protein kinase B ; BCAA ; branched-chain amino acids ; CKD ; chronic kidney disease ; CLA ; conjugated linoleic acids ; COPD ; chronic obstructive pulmonary disease ; CS ; cigarette smoke ; CSA ; cross-sectional area ; DHA ; docosahexaenoic acid ; E1 ; ubiquitin-activating enzyme ; E2 ; ubiquitin-conjugating enzyme ; E3 ; ubiquitin-ligase enzyme ; eIF3-f ; eukaryotic translation initiation factor 3-subunit F ; EPA ; eicosapentaenoic acid ; ERK ; ext
刊名：Free Radical Biology and Medicine
出版年：2016
出版时间：September 2016
年：2016
卷：98
期：Complete
页码：218-230
全文大小：959 K

文摘

•: MuRF-1 and MAFbx regulate pathological and physiological skeletal muscle atrophy.
•: 10">MuRF-1 and MAFbx are regulated by the FOXO, MAPK and NF-kB signaling pathways.
•: 15">Clinical evidence for MuRF-1 and MAFbx role in common human pathologies is lacking.
•: Lifestyle factors (nutrition, exercise, smoking, etc.) affect MuRF-1 and MAFbx regulation.
•: Inhibitors of MuRF-1 and MAFbx expression prevent muscle loss in experimental models.

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.