Molecular mechanism of Antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor β receptor degradation

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• 作者：Mei-Kuang Lu^a ; ^b ; ¹ ; ^{mklu@nricm.edu.tw} ; Tung-Yi Lin^c ; ^d ; ¹ ; Chi-Hsein Chao^a ; Chun-Hao Hu^d ; Hsien-Yeh Hsu^c ; ^d ; ^e ; ^{hsienyeh@gmail.com}
• 关键词：TGFRs ; transforming growth factor β receptors ; SPS ; sulfated polysaccharide ; NSPS ; non-sulfated polysaccharide ; FAK ; focal adhesion kinase ; Smurf2 ; Smad ubiquitination regulatory factor 2 ; UPP ; ubiquitin-proteasome pathway
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：1144-1152
• 全文大小：3149 K
• 卷排序：95

文摘

SPS inhibits the viability of lung cancer cells via the induction of cell cycle arrest. SPS activates caspase 3 and PARP. SPS inhibits TGFβ-mediated signaling pathways and cell migration. SPS induces proteasome-dependent TGFβ receptor degradation.