Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis

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Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis

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作者：Daniel R. Carter^a ; ^b ; ¹ ; Selina K. Sutton^a ; ¹ ; Marina Pajic^c ; ^d ; Jayne Murray^a ; Eric O. Sekyere^e ; Jamie Fletcher^a ; Anneleen Beckers^f ; Katleen De Preter^f ; Frank Speleman^f ; Rani E. George^g ; Michelle Haber^a ; Murray D. Norris^a ; ^h ; Belamy B. Cheung^a ; ^b ; ² ; ^{BCheung@ccia.unsw.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Glenn M. Marshall^a ; ⁱ ; ² ; ^{g.marshall@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author}
关键词：Neuroblastoma ; MYCN ; Glutathione ; Metabolomics ; Tumorigenesis ; BSO
刊名：Molecular Oncology
出版年：2016
出版时间：June 2016
年：2016
卷：10
期：6
页码：866-878
全文大小：2458 K

文摘

•: Metabolomics in TH-MYCN mice demonstrates early upregulation of glutathione biosynthesis.
•: MYCN increases protein biosynthesis to satisfy the substrate demand for glutathione production.
•: Glutathione acts as an antioxidant mechanism for pre-cancer cell survival at tumor initiation.

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