Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption

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Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption

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作者：Susu Zhang¹ ; Hongquan Dong¹ ; Xiang Zhang ; Nana Li ; Jie Sun ; ^{dgsunjie@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Yanning Qian ; ^{yanning_qian@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：POCD ; postoperative cognitive dysfunction ; BBB ; blood&ndash ; brain barrier ; CNS ; central nervous system ; ECs ; endothelial cells ; TJs ; endothelial cells ; MMP ; matrix metalloproteinase ; ECM ; extra cellular matrix ; EB ; Evans blue ; TB ; toluidine blue ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase
刊名：Behavioural Brain Research
出版年：2016
出版时间：1 February 2016
年：2016
卷：298
期：part_PB
页码：158-166
全文大小：3344 K

文摘

•: Activated mast cells are involved in neuroinflammation and cognitive dysfunction following surgery by promoting BBB disruption.
•: Mast cell stabilizer disodium cromoglycate alleviated surgery-induced cognitive decline and neuroinflammation.
•: Disodium cromoglycate inhibited the increase of BBB permeability induced by surgery.

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