Signal transducer and activator of transcription 5B (STAT5B) modulates adipocyte differentiation via MOF

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

Signal transducer and activator of transcription 5B (STAT5B) modulates adipocyte differentiation via MOF

详细信息查看全文

作者：Peng Gao^a ; ^{gaopengts@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yuchao Zhang^a ; ^b ; ^{yc.zhang@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Yuantao Liu^c ; ^{sduliuyuantao@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jicui Chen^a ; ^{chenjc1988@126.com" class="auth_mail" title="E-mail the corresponding author} ; Chen Zong^a ; ^{zongchen1203@163.com" class="auth_mail" title="E-mail the corresponding author} ; Cong Yu^a ; ^{yc-1127@163.com" class="auth_mail" title="E-mail the corresponding author} ; Shang Cui^a ; ^{csup123@yeah.net" class="auth_mail" title="E-mail the corresponding author} ; Weina Gao^a ; ^{weinana0398@163.com" class="auth_mail" title="E-mail the corresponding author} ; Dandan Qin^a ; ^{18364135491@163.com" class="auth_mail" title="E-mail the corresponding author} ; Wenchuan Sun^d ; ^{sunwenchuan111@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xia Li^a ; ^{lixia1666@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xiangdong Wang^a ; ^e ; ^{xdongw@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：C/EBPα ; CCAAT/enhancer-binding protein α ; ChIP ; chromatin immunoprecipitation ; Fabp4 ; fatty acid-binding protein 4 ; HFD ; high fat diet ; MOF ; Males absent on the first ; PPARγ ; peroxisome proliferator-activated receptor γ ; STAT5B ; signal transducer and activator of transcription 5B ; KD ; knock-down
刊名：Cellular Signalling
出版年：2015
出版时间：December 2015
年：2015
卷：27
期：12
页码：2434-2443
全文大小：1613 K

文摘

•: Knocking-down either STAT5B or MOF can promote adipocyte differentiation in 3 T3-L1 preadipocytes.
•: STAT5B modulates MOF expression by binding to its promoter.
•: Over-expression MOF inhibits C/EBPα promoter trans-activation.
•: STAT5B negatively modulates adipogenesis via regulating MOF.
•: STAT5B and MOF is negative regulator of adipocyte differentiation.