Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice

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Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice

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作者：Rick van der Geest^a ; ^{r.van.der.geest@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author} ; Amber B. Ouweneel^a ; ^{a.b.ouweneel@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author} ; Ronald J. van der Sluis^a ; ^{r.vandersluis@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author} ; Albert K. Groen^b ; ^{a.k.groen@umcg.nl" class="auth_mail" title="E-mail the corresponding author} ; Miranda Van Eck^a ; ^{m.eck@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author} ; Menno Hoekstra^a ; ^{hoekstra@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author}
关键词：ABCB4 ; ATP-binding cassette transporter B4 ; ADX ; adrenalectomy ; ALT/GPT ; alanine transaminase/glutamic pyruvic transaminase ; ANIT ; alpha-naphthylisothiocyanate ; APOA4 ; apolipoprotein A4 ; BSEP/ABCB11 ; bile salt efflux pump ; CYP7A1 ; cholesterol 7alpha-hydroxylase ; FXR/BAR ; farnesoid X receptor/bile acid receptor ; HDL ; high-density lipoprotein ; HMGCR ; HMG-CoA reductase ; LDL ; low-density lipoprotein ; LDLR ; low-density lipoprotein receptor ; NTCP1/SLC10A1 ; sodium/bile acid cotransporter member 1 ; PEPC
刊名：Toxicology and Applied Pharmacology
出版年：2016
出版时间：1 September 2016
年：2016
卷：306
期：Complete
页码：1-7
全文大小：1027 K

文摘

•: Cholestasis is associated with increased plasma glucocorticoid levels in mice.
•: Adrenalectomy lowers cholestasis-associated liver injury and hypercholesterolemia.
•: GR antagonist RU-486 similarly improves the cholestasis phenotype.
•: Endogenous glucocorticoids promote re-uptake of circulating bile acids into liver.

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