Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes

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Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes

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作者：Xiaojiaoyang Li^a ; Runping Liu^c ; Linxi Yu^a ; Zihang Yuan^a ; Rong Sun^d ; Hang Yang^a ; Luyong Zhang^a ; ^b ; Zhenzhou Jiang^a ; ^b ; ^{beaglejiang@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：ANIT ; alpha-naphthylisothiocyanate ; A1AR ; A1 adenosine receptor ; FXR ; farnesoid X receptor ; SHP ; small heterodimer partner ; Bsep ; bile salt export pump ; Mrp2 ; multidrug resistance-associated protein 2 ; Ntcp ; Na+-dependent taurocholate cotransporter ; Oatp2 ; organic anion transporters 2 ; Mrp3 ; multidrug resistance-associated protein 3 ; AMPK ; AMP-activated protein kinase ; LKB1 ; liver kinase B1 ; ERK1/2 ; extracellular regulated protein kinases 1/2 ; PKA ; cyclic AMP dependent protein kinase
刊名：Toxicology
出版年：2016
出版时间：31 August 2016
年：2016
卷：370
期：Complete
页码：106-115
全文大小：3179 K

文摘

•: ANIT activates AMPK phosphorylation via ERK1/2-LKB1 pathways.
•: ANIT-induced FXR inhibition contributes to hepatic bile acid accumulation.
•: AMPK inhibitor CC has hepatoprotection role in ANIT-induced cholestatic liver injury.

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