Definitive proton beam therapy for adenoid cystic carcinoma of the nasopharynx involving the base of skull

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• 作者：Michelle S. Gentile ; Darwin Yip ; Norbert J. Liebsch ; Judith A. Adams ; Paul M. Busse ; Annie W. Chan ; ^{awchan@mgh.harvard.edu}
• 关键词：Adenoid cystic carcinoma ; Nasopharynx ; Minor salivary gland ; Proton beam therapy ; Base of skull
• 刊名：Oral Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：65
• 期：Complete
• 页码：38-44
• 全文大小：718 K
• 卷排序：65

文摘

Outcomes for unresectable ACC of the nasopharynx treated with photons are poor. Proton beam therapy provides conformal treatment and decreased dose to normal tissue. Twenty-one percent of patients developed late local recurrence at five years after therapy. The most common cause of death was due to metastatic disease. Grade 3 or higher acute and late toxicites were 7% and 21%, respectively.