Time course of tissue remodelling and electrophysiology in the rat sciatic nerve after spiral cuff electrode implantation

详细信息    查看全文

• 作者：Marie-Anne Thil ; Dai Tran Duy ; Ides M. Colin ; Jean Delbeke
• 关键词：Electrode impedance ; Rheobase ; Chronaxie ; Nitric oxide synthase III ; Vascular endothelial growth factor ; Vasa nervorum
• 刊名：Journal of Neuroimmunology
• 出版年：2007
• 出版时间：April 2007
• 年：2007
• 卷：185
• 期：1-2
• 页码：103-114
• 全文大小：703 K

文摘

Implantation of nerve cuff electrodes induces inflammatory cell infiltration and loose connective tissue accumulation. Along with time, morphological changes evolve towards a thicker epi/perineurium as part of mechanisms that protect nerve functionality when a foreign body is wrapped around it. The rise in electrode impedance is linked to the nature of the epineurial tissue. Changes involve an increased expression of neuroprotective factors that is stronger in the endoneurium with axonal degeneration. Our data indicate that epineurial and endoneurial changes after electrode cuff implantation are part of axonal protection mechanisms. Their control is important to improve the yield of FES applications.