Neuronal Pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer’s disease spectrum

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Neuronal Pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer’s disease spectrum

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作者：Ashley Swanson^a ; ¹ ; A.A. Willette^a ; ^b ; ^c ; ¹ ; ^{awillett@iastate.edu" class="auth_mail" title="E-mail the corresponding author} ; for the Alzheimer&rsquo ; s Disease Neuroimaging Initiative²
关键词：Alzheimer&rsquo ; s disease ; Medial temporal lobe ; Inflammation ; Immunology ; Amyloid ; Tau ; Memory ; Biomarkers ; NPTX2 ; C3LP1
刊名：Brain, Behavior, and Immunity
出版年：2016
出版时间：November 2016
年：2016
卷：58
期：Complete
页码：201-208
全文大小：1905 K

文摘

•: Synapse plasticity and microglial markers best predict Alzheimer’s disease outcomes.
•: NPTX2 predicts 28.7% and 56% of MTL atrophy and memory decline by 24 months.
•: C3LP1 predicts 8.3% of MTL atrophy over time, but not memory decline by 24 months.

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