Substance-P alleviates dextran sulfate sodium-induced intestinal damage by suppressing inflammation through enrichment of M2 macrophages and regulatory T cells

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• 作者：Hyun Sook Hong^a ; ^{hshong@khu.ac.kr} ; Dae Yeon Hwang^c ; Ju Hyeong Park^b ; Suna Kim^b ; Eun Jung Seo^c ; Youngsook Son^b ; ^{ysson@khu.ac.kr}
• 关键词：DSS ; dextran sodium sulfate ; FACS ; fluorescence-activated cell sorting ; IBD ; inflammatory bowel disease ; MLN ; mesenteric lymph node ; NK-1R ; neurokinin - 1 receptor ; SP ; substance-P ; SD ; standard deviation ; Treg ; regulatory T cell
• 刊名：Cytokine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：21-30
• 全文大小：2966 K
• 卷排序：90

文摘

SP can enrich proliferating cell pool in DSS-induced intestinal damages. SP exerted anti-inflammatory effect on DSS-induced IBD by controlling cytokine profile. SP protected intestine from DSS-induced tissue destruction.