The neurological effects of ghrelin in brain diseases: Beyond metabolic functions

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• 作者：Qian Jiao^a ; ^b ; ¹ ; ^{jiaoqian2006@126.com} ; Xixun Du^a ; ^b ; ¹ ; ^{xunxundu@163.com} ; Yong Li^a ; ^b ; ^{liyong_55@sina.cn} ; Bing Gong^a ; ^{gongxian666@163.com} ; Limin Shi^a ; ^b ; ^{slm0532@163.com} ; Tingting Tang^a ; ^b ; ^{sunnyting1230@126.com} ; Hong Jiang^a ; ^b ; ^{hongjiang@qdu.edu.cn}
• 关键词：ACCα ; acetyl-CoA carboxylase α ; AD ; Alzheimer&rsquo ; s disease ; ALS ; amyotrophic lateral sclerosis ; AMPARs ; α-amino-3-hydroxy-5- methyl-4-isoxazole propionic-type receptors ; AgRP ; agouti-related protein ; AMPK ; adenosine monophosphate-activated protein kinase ; ARH ; arcuate nucleus of hypothalamus ; ATF ; activating transcription factor ; BBB ; blood&ndash ; brain barrier ; CaMKII ; Ca2+/calmodulin dependent protein kinase II ; CART ; cocaine and amphetamine regulated transcriptpeptide ; DG ; dentate gyrus ; DM
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：98-111
• 全文大小：2253 K
• 卷排序：73

文摘

Ghrelin is attracted more attention for its neuroprotective and neurogenesis roles. Ghrelin modulates numerous neuronal behaviors in pathological conditions. Ghrelin promotes neurogenesis through stimulating neural stem/progenitor cells proliferation, differentiation and migration. Ghrelin regulates synaptic plasticity and electrophysiological activity which may influence advanced brain functions.