Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

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• 作者：Katharine Askew¹ ; Kaizhen Li² ; Adrian Olmos-Alonso¹ ; Fernando Garcia-Moreno³ ; Yajie Liang² ; Philippa Richardson¹ ; Tom Tipton⁴ ; Mark A. Chapman¹ ; Kristoffer Riecken⁵ ; Sol Beccari⁶ ; Amanda Sierra⁶ ; Zolt&aacute ; n Moln&aacute ; r³ ; Mark S. Cragg⁴ ; Olga Garaschuk² ; V. Hugh Perry¹ ; Diego Gomez-Nicola¹ ; ⁷ ; ^{d.gomez-nicola@soton.ac.uk}
• 关键词：self-renewal ; BrdU ; CSF1R ; CX3CR1 ; Macgreen ; Vav-Bcl2 ; RNA-seq
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：391-405
• 全文大小：6925 K
• 卷排序：18

文摘

The microglial population is formed without the perinatal infiltration of monocytes The microglial density remains remarkably stable over a mouse or human lifetime In the mouse and human brain, microglia turn over several times during a lifetime Microglia self-renewal is maintained by coupled proliferation and apoptosis