Anti-heparanase activity of ultra-low-molecular-weight heparin produced by physicochemical depolymerization

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Anti-heparanase activity of ultra-low-molecular-weight heparin produced by physicochemical depolymerization

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作者：Oussama Achour ; Nicolas Poupard ; Nicolas Bridiau ; Stephanie Bordenave Juchereau ; Fredé ; ric Sannier ; Jean-Marie Piot ; Ingrid Fruitier Arnaudin ; Thierry Maugard ; ^{tmaugard@univ-lr.fr" class="auth_mail" title="E-mail the corresponding author}
关键词：Heparin ; Ultrasonic-assisted radical hydrolysis ; Heparinase I-catalyzed 尾-elimination ; Glycol-split ; Heparanase ; Anti-angiogenesis
刊名：Carbohydrate Polymers
出版年：2016
出版时间：1 January 2016
年：2016
卷：135
期：Complete
页码：316-323
全文大小：1057 K

文摘

•: Production of ultrasonic Ultra Low Molecular Weight Heparin (usULMWH).
•: Innovative ultrasonic assisted radical depolymerization of heparin produced usULMWH.
•: usULMWH structure and biological activities were compared to others heparins.
•: usULMWH have high anti-heparanase activity and moderate anticoagulant activities.
•: usULMWH might be potential anti-angiogenic candidates for cancer therapy.

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