Impairment of contextual fear extinction by chronic nicotine and withdrawal from chronic nicotine is associated with hippocampal nAChR upregulation

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Impairment of contextual fear extinction by chronic nicotine and withdrawal from chronic nicotine is associated with hippocampal nAChR upregulation

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作者：Munir Gunes Kutlu^a ; ^{munir.kutlu@temple.edu" class="auth_mail" title="E-mail the corresponding author} ; Chicora Oliver^a ; Peng Huang^b ; Lee-Yuan Liu-Chen^b ; Thomas J. Gould^a
关键词：Nicotine ; Nicotinic receptors ; Extinction ; PTSD
刊名：Neuropharmacology
出版年：2016
出版时间：October 2016
年：2016
卷：109
期：Complete
页码：341-348
全文大小：2093 K

文摘

•: Contextual fear extinction was impaired both during chronic nicotine administration and subsequent withdrawal.
•: The effects of prior chronic nicotine disappeared after 72 hr in withdrawal.
•: Four days of continuous nicotine administration upregulated hippocampal nAChRs and impaired contextual fear extinction.

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