Elevated kynurenine pathway metabolism during neurodevelopment: Implications for brain and behavior

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• 作者：Francesca M. Notarangelo ; Ana Pocivavsek ; ^{apocivavsek@mprc.umaryland.edu}
• 关键词：Kynurenic acid ; Schizophrenia ; Cognition ; Alpha 7 nicotinic receptor ; Choline
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：112
• 期：part_PB
• 页码：275-285
• 全文大小：993 K
• 卷排序：112

文摘

Kynurenine pathway metabolite levels are higher during gestation and decrease after birth. Environmental insults and genetic manipulations affect kynurenine pathway metabolism. Review of perinatal kynurenine pathway manipulations to study neuropathology and behavior of neurodevelopmental disorders. Interventions targeting KP enzymes or sites of action may constitute novel therapeutic strategies in psychiatric disorders.