Direct amidation of aniline derivatives with 1,1-dichloro-2-nitroethene in water

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• 作者：Fengjuan Zhu^a ; Xue Tian^a ; Xusheng Shao^a ; ^{shaoxusheng@ecust.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Zhong Li^a ; ^b
• 关键词：Green methodology ; Direct amidation ; 1 ; 1-Dichloro-2-nitroethene ; N-nitroacetylation
• 刊名：Tetrahedron Letters
• 出版年：2015
• 出版时间：21 October 2015
• 年：2015
• 卷：56
• 期：43
• 页码：5945-5949
• 全文大小：1190 K

文摘

A green methodology was established for direct amidation of anilines using 1,1-dichloro-2-nitroethene. The new protocol provides convenient N-nitroacetylation for the anilines. This method was applicable to anilines include anthranilic acids, anthranilamides, phenylbenzohydrazides, diphenylamine, and 2-aminobenzenesulfonamide. The amidation process was accomplished in water and the products can be easily separated by filtration.