Leukemia inhibitory factor receptor (LIFR) is detected as a novel suppressor gene of hepatocellular carcinoma using double-combination array

详细信息    查看全文

• 作者：Yukiyasu Okamura ; Shuji Nomoto ; Mitsuro K ; a ; Qiyong Li ; Yoko Nishikawa ; Hiroyuki Sugimoto ; Naohito Kanazumi ; Shin Takeda ; Akimasa Nakao
• 关键词：Hepatocellular carcinoma ; Leukemia inhibitory factor receptor ; Tumor suppressor gene ; Expression array ; Single nucleotide polymorphism array
• 刊名：Cancer Letters
• 出版年：2010
• 出版时间：28 March 2010
• 年：2010
• 卷：289
• 期：2
• 页码：170-177
• 全文大小：969 K

文摘

Hepatocellular carcinoma (HCC) is one of the world’s top five causes of cancer-related deaths and treatment options are limited in this type of cancer. In the present study, we attempt to identify the novel suppressor genes of HCC using a double-combination array we designed. Leukemia inhibitory factor receptor (LIFR) is one of suppressor genes using this method. We found that 23 of 48 (47.9 % ) tumor tissues showed promoter hypermethylation of LIFR gene, and the expression level was clearly reduced in tumor tissues (P < 0.0001). The present study suggests that our method is a meaning technique able to detect novel genes and that LIFR gene is a new suppressor gene of HCC.