Inward rectifier K⁺ channel and T-type Ca^{2 +} channel contribute to enhancement of GABAergic transmission induced by β₁-adrenoceptor in the prefrontal cortex

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• 作者：Fei Luo ; ^{luofei@ncu.edu.cn} ; Jian Zheng ; Xuan Sun ; Hua Tang
• 关键词：ACSF ; artificial cerebral spinal fluid ; AHP ; afterhyperpolarization ; AP ; action potential ; Dobu ; dobutamine ; FS ; fast-spiking ; IRKC ; inwardly rectifying K+ current ; Kir ; inward rectifier K+ channel ; NE ; norepinephrine ; NMDG ; N-methyl-d-glucamine ; PFC ; prefrontal cortex ; PPF ; paired-pulse facilitation ; PTX ; picrotoxin ; TTX ; tetrodotoxin
• 刊名：Experimental Neurology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：288
• 期：Complete
• 页码：51-61
• 全文大小：2574 K
• 卷排序：288

文摘

Dobutamine enhances GABAergic transmission onto pyramidal neurons. T-type Ca2 + channel is involved in dobutamine-enhanced GABA release. Dobutamine depolarizates GABAergic interneurons through inhibition of Kir.