Integrated transcriptomic and metabolomic analysis shows that disturbances in metabolism of tumor cells contribute to poor survival of RCC patients

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• 作者：Piotr Popławski^a ; Takayuki Tohge^b ; Joanna Bogusławska^a ; Beata Rybicka^a ; Zbigniew Tański^c ; Victor Trevi&ntilde ; o^d ; Alisdair R. Fernie^b ; Agnieszka Piekiełko-Witkowska^a ; ^{apiekielko@cmkp.edu.pl}
• 关键词：RCC ; renal cell carcinoma ; ccRCC ; clear cell renal cell carcinoma ; qPCR ; quantitative real-time PCR
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1863
• 期：3
• 页码：744-752
• 全文大小：1382 K
• 卷排序：1863

文摘

GC-MS analysis revealed altered levels of 31 metabolites in RCC tumors. Top changed metabolites included succinate, purines, myo-inositol, urea, and beta-alanine. qPCR arrays detected disturbed expression of 53 metabolic genes. Impaired expression of metabolic genes correlates with poor survival of RCC patients. First report of link between poor survival and myo-inositol/beta-alanine metabolism.