Effects of chronic deoxynivalenol exposure on p53 heterozygous and p53 homozygous mice

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Effects of chronic deoxynivalenol exposure on p53 heterozygous and p53 homozygous mice

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作者：G.S. Bondy ; ^{Genevieve.Bondy@canada.ca" class="auth_mail" title="E-mail the corresponding author} ; L. Coady ; I. Curran ; D. Caldwell ; C. Armstrong ; S.A. Aziz ; A. Nunnikhoven ; A.M. Gannon ; V. Liston ; J. Shenton¹ ; R. Mehta
关键词：Deoxynivalenol ; Mouse ; p53 ; Chronic ; Diet ; Inflammation ; Cancer
刊名：Food and Chemical Toxicology
出版年：2016
出版时间：October 2016
年：2016
卷：96
期：Complete
页码：24-34
全文大小：443 K

文摘

•: Deoxynivalenol did not produce tumours in cancer-prone p53+/− mice.
•: Deoxynivalenol caused feed refusal and reduced body weight gain in mice.
•: Deoxynivalenol induced gene expression changes indicative of anti-inflammatory and anti-proliferative responses in mice.

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