Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds

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Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds

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作者：B&uuml ; nyamin Ö ; zgeriş^a ; ^b ; S&uuml ; leyman Gö ; ksu^b ; ^{sgoksu@atauni.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Leyla Polat Kö ; se^b ; İlhami G&uuml ; lç ; in^b ; ^c ; ^{igulcin@atauni.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Ramin Ekhteiari Salmas^d ; Serdar Durdagi^d ; Ferhan T&uuml ; mer^e ; Claudiu T. Supuran^f ; ^g
关键词：Acetylcholine esterase ; Carbonic anhydrase ; Enzyme inhibition ; Sulfamide ; Urea ; Molecular docking ; Molecular dynamics (MD) simulations
刊名：Bioorganic & Medicinal Chemistry
出版年：2016
出版时间：15 May 2016
年：2016
卷：24
期：10
页码：2318-2329
全文大小：2380 K

文摘

•: Three novel sulfamides derived from 2-aminotetralins were synthesized.
•: Three novel ureas derived from 2-aminotetralins were synthesized.
•: Synthesized sulfamide and ureas were converted to their phenolic derivatives.
•: The compounds showed effective hCA I, II and AChE inhibition.
•: The molecular mechanisms of inhibitions were investigated by in silico studies.