Rapid isolation of peptidic inhibitors of the solute carrier family transporters OATP1B1 and OATP1B3 by cell-based phage display selections

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Rapid isolation of peptidic inhibitors of the solute carrier family transporters OATP1B1 and OATP1B3 by cell-based phage display selections

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作者：Yuko Arita^a ; Samantha Allen^b ; Gang Chen^a ; Wei Zhang^b ; Ying Wang^b ; Albert J. Owen^b ; Patrick Dentinger^b ; Sachdev S. Sidhu^a ; ^{sachdev.sidhu@utoronto.ca" class="auth_mail" title="E-mail the corresponding author}
关键词：Organic anion-transporting polypeptides ; OATP1B1 ; OATP1B3 ; Phage-display ; Peptide inhibitor
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：29 April 2016
年：2016
卷：473
期：2
页码：370-376
全文大小：1141 K

文摘

•: Identification of peptide inhibitors for OATP1B1 and OATP1B3.
•: Construction of phage-displayed peptide library with high diversity.
•: Development of phage-display selections for membrane transports using live cell.

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