Sa.26. Heterogeneity of the Psoriasis Phenotype Revealed by HLA Class I Haplotype Associations in Psoriatic Arthritis and Psoriasis

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• 作者：Robert Winchester ; Gregory Minevich ; David Kane ; Barry Bresnihan ; David Greenberg ; Oliver FitzGerald
• 关键词：Hydrogel ; Oligo[(polyethylene glycol) fumarate] (OPF) ; Marrow stromal cells ; Magnetic resonance microscopy ; Osteogenesis
• 刊名：Clinical Immunology
• 出版年：2008
• 出版时间：2008
• 年：2008
• 卷：127
• 期：Supplement 1
• 页码：S88-S89
• 全文大小：68 K

文摘

There are no validated criteria for classification; this is partly because ofthe heterogeneous clinical features associated with the disease, and the relapsing and remitting nature of both psoriasis and arthritis. Clinical subgroups have been proposed and have proved useful in study of the disease; however, there are inconsistencies and overlaps in the published data.

The population prevalence of psoriatic arthritis is in the range of 2–10 per 10 000 although this is probably an underestimate as those with sacroiliac involvement only are not included. There are currently no incidence figures from population samples. The disease is slightly more common in females than males, although there is variation in the sex ratio by disease subgroup. There is evidence that hormonal and environmental factors play a role in the occurrence of disease.