Discovery of antiviral molecules for dengue: In silico search and biological evaluation

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Discovery of antiviral molecules for dengue: In silico search and biological evaluation

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作者：Maria Cabarcas-Montalvo^a ; Wilson Maldonado-Rojas^a ; Diana Montes-Grajales^a ; Angela Bertel-Sevilla^a ; Irene Wagner-Dö ; bler^b ; Helena Sztajer^b ; Michael Reck^b ; Maria Flechas-Alarcon^c ; Raquel Ocazionez^c ; Jesus Olivero-Verbel^a ; ^{joliverov@unicartagena.edu.co" class="auth_mail" title="E-mail the corresponding author}
关键词：Dengue protease inhibitor ; NS2B/NS3 complex ; Molecular docking ; In vitro inhibition ; Inhibitory activity
刊名：European Journal of Medicinal Chemistry
出版年：2016
出版时间：3 March 2016
年：2016
卷：110
期：Complete
页码：87-97
全文大小：1571 K

文摘

•: In silico-in vitro assays were performed to find Dengue virus protease inhibitors.
•: Three molecules showed promising inhibitory activity against DENV2 protease.
•: Bis(4hydroxy2oxo2Hchromen3yl) (2methoxyphenyl)methyl is an anti-dengue motif.

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