Megastigmane glycosides from leaves of Eucommia ulmoides Oliver with ACE inhibitory activity

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• 作者：Jian-Kun Yan^a ; ^c ; Li-Qin Ding^c ; Xu-Liu Shi^b ; ^c ; Paul Owusu Donkor^b ; ^c ; Li-Xia Chen^a ; ^{syzyclx@163.com} ; Feng Qiu^a ; ^b ; ^c ; ^{fengqiu20070118@163.com}
• 关键词：Leaves of Eucommia ulmoides Oliver ; Megastigmane glycosides ; Eucomegastigsides ; Angiotensin converting enzyme (ACE)
• 刊名：Fitoterapia
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：116
• 期：Complete
• 页码：121-125
• 全文大小：411 K
• 卷排序：116

文摘

Four new megastigmane glycosides, eucomegastigsides A-D (2, 3, 5 and 7), together with three known megastigmane glycosides, (6R, 7E, 9R)-9-hydroxy-4, 7-megastigmadien-3-one-9-O-[α-l-arabinopyranosyl-(l → 6)-β-d-glucopyranoside (1), foliasalacioside B1 (4) and eleganoside A (6), were isolated from the leaves of Eucommia ulmoides Oliver. Their anti-hypertensive effect was investigated in vitro based on the inhibition of Angiotensin Converting Enzyme (ACE) using HPLC. The results showed that the isolates (2, 3, 4, 5, 7) had moderate inhibitory effects on ACE in vitro compared with captopril.