Marked efficacy of a therapeutic strategy associating prednisone and plasma exchange followed by rituximab in two patients with refractory myopathy associated with antibodies to the signal recognition

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Marked efficacy of a therapeutic strategy associating prednisone and plasma exchange followed by rituximab in two patients with refractory myopathy associated with antibodies to the signal recognition

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作者：Jean-Benoit Arlet ; Dalia Dimitri ; Christian Pagnoux ; Olivier Boyer ; Thierry Maisonobe ; Franç ; ois-Jé ; rome Authier ; Coralie Bloch-Queyrat ; Claire Goulvestre ; Farhad Heshmati ; Marielle Atassi
关键词：Myopathy ; Rituximab ; Anti-SRP antibodies ; Signal recognition particle ; T-cell repertoire
刊名：Neuromuscular Disorders
出版年：2006
出版时间：May 2006
年：2006
卷：16
期：5
页码：334-336
全文大小：179 K

文摘

We report two patients with myopathy associated with anti-signal recognition particle Ab, refractory to conventional therapy, who were treated with prednisone and plasma exchange, followed by rituximab. A marked response was observed in both patients, with partial to complete recovery of muscle strength, which was sustained.