In-vivo comparison of the neurotoxic potencies of incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA

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In-vivo comparison of the neurotoxic potencies of incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA

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作者：Anna Kutschenko ; ^{anna.kutschenko@med.uni-goettingen.de" class="auth_mail" title="E-mail the corresponding author} ; Anja Manig ; Marie-Christine Reinert ; Angelika Mö ; nnich ; David Liebetanz
关键词：BoNT ; botulinum neurotoxin ; BoNT/A-G ; botulinum neurotoxin type A-G ; A/Inco ; incobotulinumtoxinA (Xeomin® ; ) ; A/Ona ; onabotulinumtoxinA (Botox® ; ) ; A/Abo ; abobotulinumtoxinA (Dysport® ; ) ; DAS assay ; digit abduction score assay ; MU ; mouse unit ; Vmax ; maximum running velocity ; ANOVA ; analysis of variance
刊名：Neuroscience Letters
出版年：2016
出版时间：3 August 2016
年：2016
卷：627
期：Complete
页码：216-221
全文大小：704 K

文摘

•: IncobotulinumtoxinA, onabotulinumtoxinA, abobotulinumtoxinA are not interchangeable.
•: The same number of mouse units induces different degrees of paresis.
•: OnabotulinumtoxinA is relevantly more potent than incobotulinumtoxinA.
•: The potency of onabotulinumtoxinA is two-fold greater than of abobotulinumtoxinA.
•: The same value of paresis also results in an identical duration of paresis.

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