Allele-Level HLA Matching Impacts Key Outcomes Following Umbilical Cord Blood Transplantation for Inherited Metabolic Disorders

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• 作者：Kanwaldeep K. Mallhi¹ ; Angela R. Smith¹ ; Todd E. DeFor² ; Troy C. Lund¹ ; Paul J. Orchard¹ ; Weston P. Miller¹ ; ^{mill4991@umn.edu}
• 关键词：Stem cell transplantation ; Inherited metabolic disorders ; Engrafted survival outcomes ; High resolution ; Allelic HLA ; Umbilical cord
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：23
• 期：1
• 页码：119-125
• 全文大小：1040 K
• 卷排序：23

文摘

Analysis of allele-level HLA matching impacted key post-umbilical cord blood transplantation outcomes for inherited metabolic disorderss. Greater allelic HLA match predicts better survival and high chimerism. Greater allelic HLA match predicts lower graft failure and transplantation-related mortality.