Hypervalent organotellurium compounds as inhibitors of P. falciparum calcium-dependent cysteine proteases

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Hypervalent organotellurium compounds as inhibitors of P. falciparum calcium-dependent cysteine proteases

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作者：Sarah El Chamy Maluf^a ; ¹ ; Pollyana M.S. Melo^a ; ¹ ; Fernando P. Varotti^b ; Marcos L. Gazarini^c ; Rodrigo L.O.R. Cunha^d ; Adriana K. Carmona^a ; ^{ak.carmona@unifesp.br" class="auth_mail" title="E-mail the corresponding author}
关键词：Plasmodium ; Malaria ; Calpain ; Tellurium compounds
刊名：Parasitology International
出版年：2016
出版时间：February 2016
年：2016
卷：65
期：1
页码：20-22
全文大小：375 K

文摘

•: Organotelluranes inhibited calcium dependent cysteine proteases of P. falciparum
•: RF05, RF07 and RF19 present antimalarial activity in two P. falciparum strains
•: Organotelluranes did not cause hemolysis or decrease HUVEC viability in the concentrations used in inhibition assays

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