Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics

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Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics

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作者：Marie Austdal^a ; ^b ; ^e ; ^{marie.austdal@ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Liv Cecilie Vestrheim Thomsen^c ; ^d ; ^e ; ^{liv.vestrheim@uib.no" class="auth_mail" title="E-mail the corresponding author} ; Line Haugstad Tangerå ; s^b ; ^e ; ^{line.tangeraas@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Bente Skei^e ; ^{bente.skei@ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Seema Mathew^c ; ^{seemamathew.sm@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Line Bj&oslash ; rge^c ; ^d ; ^{line.bjorge@uib.no" class="auth_mail" title="E-mail the corresponding author} ; Rigmor Austgulen^e ; ^{rigmor.austgulen@ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Tone Frost Bathen^a ; ^{tone.f.bathen@ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Ann-Charlotte Iversen^e ; ^{ann-charlotte.iversen@ntnu.no" class="auth_mail" title="E-mail the corresponding author}
关键词：Preeclampsia ; Metabolomics ; Placenta ; Metabolism ; Profiling ; NMR
刊名：Placenta
出版年：2015
出版时间：December 2015
年：2015
卷：36
期：12
页码：1455-1462
全文大小：854 K

文摘

•: The largest metabolic profiling of preeclamptic placentas to date.
•: Metabolic pathways are differently expressed in preeclamptic and normotensive placentas.
•: Metabolite changes in preeclampsia involve taurine and phospholipids.
•: Metabolic profiles correlate to maternal serum measurements.
•: Novel, sensitive, and nondestructive method for placental tissue profiling.

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