Maternal stress modifies the effect of exposure to lead during pregnancy and 24-month old children's neurodevelopment

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• 作者：Marcela Tamayo y Ortiz^a ; ^{mtamayo@hsph.harvard.edu} ; Martha Marí ; a Té ; llez-Rojo^b ; ^{mmtellez@insp.mx} ; Belem Trejo-Valdivia^b ; ^{bvaldivia@insp.mx} ; Lourdes Schnaas^c ; ^{lschnaas@hotmail.com} ; Erika Osorio-Valencia^c ; ^{erikaosorio4@hotmail.com} ; Brent Coull^d ; ^{bcoull@hsph.harvard.edu} ; David Bellinger^e ; ^{david.bellinger@childrens.harvard.edu} ; Rosalind J. Wright^f ; ^{rosalind.wright@mssm.edu} ; Robert O. Wright^g ; ^{robert.wright@mssm.edu}
• 关键词：Prenatal ; Neurodevelopment ; Lead ; Stress ; Effect modification
• 刊名：Environment International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：98
• 期：Complete
• 页码：191-197
• 全文大小：763 K
• 卷排序：98

文摘

Lead and stress were negatively associated with Bayley III neurodevelopment scores. For lead levels < 2 μg/dL there was a dose–response for stress with both scores. Prenatal stress exposure modified the neurotoxic effects of prenatal lead. Higher prenatal stress resulted in lower cognitive scores. Further modification by sex was seen for language scores.