Microscale mechanical and mineral heterogeneity of human cortical bone governs osteoclast activity

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• 作者：K. Pernelle^a ; ^b ; L. Imbert^a ; ^c ; C. Bosser^a ; J-C. Auregan^a ; ^d ; M. Cruel^a ; A. Ogier^a ; P. Jurdic^b ; T. Hoc^a ; ^{thierry.hoc@ec-lyon.fr}
• 关键词：Osteoclasts ; Biomechanics ; Matrix mineralization ; Nano indentation ; Raman spectroscopy
• 刊名：Bone
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：Complete
• 页码：42-49
• 全文大小：1139 K
• 卷排序：94

文摘

We measured surface topography of human cortical bone before and after osteoclast resorption. We showed that human osteoclasts resorb specific osteons of human cortical bone. Nanoindentation showed a significantly lower Young’s modulus in resorbed versus unresorbed osteons. We report a decrease in mineral content of resorbed osteons associated with smaller crystallinity.