• 作者：N. Belkahla ; H. Kchir ; N. Maamouri ; H. Ouerghi ; F.B. Hariz ; S. Chouaib ; H. Chaabouni ; N.B. Mami
• 关键词：Hepatitis C ; Tuberculosis ; Treatment
• 刊名：La Revue de Medecine Interne
• 出版年：2010
• 出版时间：November 2010
• 年：2010
• 卷：31
• 期：11
• 页码：e1-e3
• 全文大小：132 K

Hepatitis C viral infection can be associated with other infectious diseases including viral and bacterial infections such as tuberculosis. Mycobacterium tuberculosis infection may be latent for many years and revealed during an immunodeficiency state. The responsibility of antiviral treatment in the reactivation of tuberculosis is controversial. We report two cases of tuberculous reactivation during bitherapy with pegylated interferon and ribavirin for chronic hepatitis C. A rapid viral response was obtained in both cases. Tuberculous reactivation occurred at 12 and 13 weeks of antiviral treatment, respectively. Tuberculosis involved urinary tract in one patient and lymph nodes in the other. Antituberculous treatment was given and antiviral treatment maintained. The outcome of tuberculosis was favourable and a sustained viral response was obtained for both patients.