Obaculactone protects against bleomycin-induced pulmonary fibrosis in mice

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Obaculactone protects against bleomycin-induced pulmonary fibrosis in mice

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作者：Xingqi Wang ; Zijun Ouyang ; Qian You ; Shuai He ; Qianqian Meng ; Chunhui Hu ; Xudong Wu ; Yan Shen ; Yang Sun ; ^{yangsun@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xuefeng Wu ; ^{wuxf@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Qiang Xu ; ^{molpharm@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Obaculactone ; Pulmonary fibrosis ; Bleomycin ; TGF-β1 ; Drug candidate
刊名：Toxicology and Applied Pharmacology
出版年：2016
出版时间：15 July 2016
年：2016
卷：303
期：Complete
页码：21-29
全文大小：2156 K

文摘

•: Obaculactone ameliorates bleomycin-induced pulmonary fibrosis in mice.
•: Obaculactone mitigates bleomycin-induced inflammatory response in lungs.
•: Obaculactone exerts inhibitory effects on TGF-β1 signaling and TGF-β1-induced EMT progress.

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