Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats

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Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats

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作者：Krystyna Ossowska^a ; ^{ossowska@if-pan.krakow.pl" class="auth_mail} ; Jadwiga Wardas^a ; Klemencja Berghauzen-Maciejewska^a ; Urszula G艂owacka^a ; Katarzyna Kuter^a ; Andrzej Pilc^b ; Stevin H. Zorn^c ; Dario Doller^c
关键词：Tremor ; Hyperactivation ; Harmaline ; Metabotropic glutamate receptor 4 ; Cerebellum ; Inferior olive
刊名：Neuropharmacology
出版年：August 2014
年：2014
卷：83
期：Complete
页码：28-35
全文大小：1271 K

文摘

•: Harmaline evoked tremor and hyperactivity in rats.
•: Harmaline decreased mGlu4 mRNA expression in the cerebellum and inferior olive.
•: mGlu4 positive allosteric modulator reversed the harmaline-induced hyperactivity.
•: mGlu4 positive allosteric modulator did not influence the harmaline-induced tremor.
•: mGlu4 stimulation may affect cerebellar glutamatergic transmission.

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