Thiol-induced nitric oxide donation mechanisms in substituted dinitrobenzofuroxans

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• 作者：Mikhail E. Kletskii ; Oleg N. Burov ; ^{bboleg@gmail.com} ; Nikita S. Fedik ; Sergey V. Kurbatov
• 关键词：Furoxan ; Nitrogen(II) oxide ; DFT calculations ; Thiol-induced NO donation mechanism
• 刊名：Nitric Oxide
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：62
• 期：Complete
• 页码：44-51
• 全文大小：992 K
• 卷排序：62

文摘

Dinitrofuroxans with π-donor substituents in the position 7 are prone to N-oxidic tautomerism. Furoxans easier donate NO in the 3-N-oxide form than in 1-N-oxide form. 7-Substituted furoxans are not affected by the Boulton-Katritzky reaction. 7-Substituted dinitrofuroxans exist in two atropisomeric forms. NO donation is easier in anti atropisomer.