The reactivity of lactyl-oxythiamin implies the role of the amino-pyrimidine in thiamin catalyzed decarboxylation

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The reactivity of lactyl-oxythiamin implies the role of the amino-pyrimidine in thiamin catalyzed decarboxylation

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作者：Yasaman Heidari¹ ; Graeme W. Howe ; Ronald Kluger ; ^{r.kluger@utoronto.ca" class="auth_mail" title="E-mail the corresponding author}
关键词：Oxythiamin ; Thiamin ; Lactyl-oxythiamin synthesis ; Lactyl-oxythiamin decarboxylation ; Aminopyrimidine function ; 2-ketoacid decarboxylases ; Acyl carbanion equivalent ; Nucleophilic carbene ; Hydrogen bond
刊名：Bioorganic Chemistry
出版年：2016
出版时间：December 2016
年：2016
卷：69
期：Complete
页码：153-158
全文大小：602 K

文摘

•: LOTh, the conjugate of oxythiamin and pyruvate, was synthesized.
•: LOTh decarboxylates at only 1/4 the rate of the thiamin conjugate.
•: The rate variation is associated with differences in H-bonding.

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