Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency

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Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency

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作者：Chun Ma¹ ; ² ; Violetta Karwacki-Neisius³ ; ⁴ ; Haoran Tang¹ ; ² ; Wenjing Li¹ ; ² ; Zhennan Shi¹ ; ² ; Haolin Hu¹ ; ² ; Wenqi Xu¹ ; ² ; Zhentian Wang¹ ; ² ; Lingchun Kong¹ ; ² ; Ruitu Lv¹ ; ² ; Zheng Fan¹ ; ² ; Wenhao Zhou¹ ; Pengyuan Yang⁵ ; Feizhen Wu¹ ; ² ; Jianbo Diao¹ ; ² ; Li Tan¹ ; ² ; Yujiang Geno Shi¹ ; ⁶ ; Fei Lan¹ ; ² ; ^{fei_lan@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yang Shi¹ ; ² ; ³ ; ⁴ ; ⁷ ; ^{yshi@hms.harvard.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Nono ; p54NRB ; Erk ; RNAPII ; Neat1 ; mESC ; pluripotency ; ground state ; bivalent domain ; para-speckle
刊名：Cell Reports
出版年：2016
出版时间：18 October 2016
年：2016
卷：17
期：4
页码：997-1007
全文大小：3662 K

文摘

•: Nono loss in mESCs leads to robust self-renewal
•: Erk interacts with Nono and is required for its chromatin localization
•: Nono is required for Erk activation and RNAPIIS5P at a subset of bivalent genes
•: Nono loss compromises mESC differentiation

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