Proteasome activator subunit 3 promotes pancreatic cancer growth via c-Myc-glycolysis signaling axis

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• 作者：Jiefang Guo^a ; ¹ ; Jun Hao^b ; ¹ ; Hongxue Jiang^a ; ¹ ; Jing Jin^a ; Hongyu Wu^a ; Zhendong Jin^a ; ^{zhendjin@126.com} ; Zhaoshen Li^a ; ^{lizhaoshen111@gmail.com}
• 关键词：Pancreatic cancer ; PSME3 ; c-Myc ; Glycolysis
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：386
• 期：Complete
• 页码：161-167
• 全文大小：1416 K
• 卷排序：386

文摘

PSME3 is upregulated in pancreatic cancer cells and tissues. Upregulation of PSME3 predicts poor prognosis in pancreatic cancer. PSME3 promotes cell proliferation and invasion of pancreatic cancer. PSME3 exerts it oncogenic roles by inhibiting c-Myc degradation and thus promoting glycolysis.