Suppressing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on chocolate self-administration and reinstatement of chocolate seeking in rats

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• 作者：Irene Lorrai<sup>asup><sup> ; sup><sup>1sup> ; Paola Maccioni<sup>asup><sup> ; sup><sup>1sup> ; Mauro A.M. Carai<sup>bsup> ; Alessandro Capra<sup>csup> ; M. Paola Castelli<sup>csup> ; Antonella Riva<sup>dsup> ; Paolo Morazzoni<sup>dsup> ; Gian Luigi Gessa<sup>asup> ; Giancarlo Colombo<sup>asup><sup> ; sup><sup>colomb@unica.itsup>
• 关键词：Saikosaponin A ; Bupleurum falcatum ; Chocolate-flavored beverage ; Operant self-administration ; Reinstatement of seeking behavior ; Rats
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：638
• 期：Complete
• 页码：211-217
• 全文大小：1337 K
• 卷排序：638

文摘

Saikosaponin A is a major ingredient of the medicinal herb, Bupleurum falcatum. Saikosaponin A reduced self-administration of a chocolate-flavored beverage in rats. Saikosaponin A also reduced reinstatement of seeking for a chocolate-flavored beverage. These results extend the anti-addictive effect of saikosaponin A to a natural stimulus.